Bethesda Criteria HNPCC | Medical Algorithm

Are you evaluating a colorectal carcinoma for microsatellite instability?

Yes

Are there mutations in?

• BAT-25?

Yes

• BAT-26?

Yes

• D2S123?

Yes

• D5S346?

Yes

• D17S250?

Yes

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Total score

The microsatellite instablity is

Should additional testing with BAT40 and/or MYCL be considered?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Criteria For Diagnosis
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC): Amsterdam Criteria
Severity, Prognosis, Stage
- Prognostic Index of Graf et al for Patients with Advanced Colorectal Carcinoma
- ACPGBI (Association of Coloproctology of Great Britain and Ireland) Score for Predicting Mortality in a Patient Undergoing Resection of a Colorectal Cancer

Therapy

Options
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC): Original and Revised Bethesda Guidelines
Selection
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC): Original and Revised Bethesda Guidelines

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Therapy

Specialty

Objective

ICD-10

Bethesda Panel to Determine Microsatellite Instability (MSI) in Colorectal Carcinoma

Purpose: To detect microsatellite instability (MSI) in a colorectal carcinoma using the Bethesda panel.

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Therapy

Specialty

Objective

ICD-10