Radiation-Induced Dementia in Patient Treated for Brain Metastases

Did the patient receive aggressive whole brain or focused brain radiation therapy?

Did the patient receive high daily radiation fractions?

Was the patient treated with potentially neurotoxic chemotherapeutic agents?

Has control of intra- and extracerebral tumor allowed the patient to survive for some time?

• progressive dementia?

• ataxia?

• urinary incontinence?

• moderate to severe impairment?

• cortical atrophy?

• hypodense white matter?

• contrast-enhancing areas of radionecrosis?

• diffuse leukoencephalopathy?

• hydrocephalus?

• cerebral edema?