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Differential Diagnosis of Primary Angiitis of Central Nervous System (PACNS)

Purpose: To identify conditions that need to be excluded before the diagnosis of primary angiitis of the CNS (PACNS) can be made.

Evaluation

Are you evaluating a patient with possible primary angiitis of the central nervous system (PACNS)?

Is the patient infected with?

• Actinomcyes species?

• Aspergillus?

• Borrelia burgdorferi (Lyme disease)

• Candida albicans?

• Enterovirus?

• Falciparum malaria?

• hepatitis C virus (HCV)?

• HIV?

• influenza virus?

• JC virus?

• Mycobacterium tuberculosis?

• Mycoplasma pneumoniae?

• Parvovirus B19?

• Rickettsia infection?

• Streptococcus pneumoniae?

• Treponema pallidum (syphilis)?

• Varicella zoster?

• West Nile virus?

• other infectious agent?

Does the patient have evidence of?

• Behcet's syndrome?

• Churg-Strauss syndrome?

• Cogan's syndrome?

• graft vs host disease?

• Hashimoto's encephalitis?

• Henoch-Schonlein purpura?

• hypersensitivity vasculitis?

• inflammatory bowel disease (IBD)?

• Juvenile dermatomyositis?

• Kawasaki's disease?

• microscopic polyarteritis?

• paraneoplastic angiitis?

• polyarteritis nodosa (PAN)?

• sarcoidosis?

• Sjogren's syndrome?

• Systemic Lupus Erythematosus (SLE)?

• urticarial hypocomplementemia?

• Wegener's granulomatosis?

• other immune vasculitis?

Does the patient have evidence of?

• angiotropic and intravascular lymphoproliferative disorders?

• arterial fibromuscular dysplasia?

• cardiac myxoma with emboli?

• cholesterol atheroembolism?

• hemoglobiopathy?

• Moyamoya disease?

• radiation vasculopathy?

• small vessel arterial dissection?

• thrombotic disorders (antiphospholipid syndrome, etc)?

• other cerebral vasculopathy?

Does the patient have evidence of?

• multiple sclerosis?

• acute demyelinating encephalomyelitis?

• reversible cerebral vasoconstriction syndromes (RCVS), including BACNS and other vasospastic conditions?

Results

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Specialty

Objective

ICD-10