Ovarian Serous Carcinoma - Two-Tier System for Histologic Grading

Purpose: To grade the histologic features of an ovarian serous carcinoma using the two-tier scheme of Malpica et al.

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Evaluation

Are you evaluating histologic sections from a serous carcinoma of the ovary?

Yes

Have you selected the worst looking area from multiple sections?

Yes

Number of mitoses in 10 high powered fields

Diameter of the smallest nucleus in the area

microns

Diameter of the largest nucleus in the area

microns

Select an appropriate answer for each histologic feature

Variation in nuclear size

Variation in nuclear shape

Chromatin pattern

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Ratio of largest to smallest nuclear diameters

Number of findings suggesting a low grade tumor

Number of intermediate features

Number of findings suggesting a high grade tumor

The histologic grade of the tumor is

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Risk of Ovarian Malignancy Algorithm (ROMA) of Moore et al for Predicting an Epithelial Ovarian Cancer
Clinical Diagnosis, Including Family History For Genetics
- Weighted Scoring System of Lerner et al for Evaluating an Ovarian Mass By Transvaginal Ultrasonography (Modified Sassone Score)
Imaging Studies
- Ultrasound Scoring System of Sassone et al for Ovarian and Extrauterine Masses
Laboratory Tests
- Rajavithi-Ovarian Cancer Predictive Score (R-OPS) of Yanaranop et al
Other Testing
- Advanced Ovarian Cancer | Score for Predicting Surgical Outcome
Severity, Prognosis, Stage

Therapy

Selection
- Advanced Ovarian Cancer | Score for Predicting Surgical Outcome

Specialty

Hematology Oncology
Surgery, general
Obstetrics & Gynecology

Objective

laboratory tests
severity
prognosis
stage

ICD-10

C56 - Malignant neoplasm of ovary

Info

Purpose: To grade the histologic features of an ovarian serous carcinoma using the two-tier scheme of Malpica et al.

Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology

Objective: laboratory tests, severity, prognosis, stage

ICD-10: C56,

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