Acute Graft versus Host Disease Stages | Medical Algorithm

Evaluation

Are you evaluating a patient who has had an hematopoietic cell transplant after myeloablative conditioning?

Yes

Number of days out from the transplant

Total serum bilirubin

Does the patient have poorly controlled anorexia, nausea and vomiting?

Yes

Oral intake as percent of requirements (enter from 0 to 100)

Has the patient been treated with prednisone?

Yes

Has the patient received any secondary therapy for GVHD?

Yes

Modified ECOG performance scale

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Total activity index (aGVHDAI)

Probability of nonrelapse mortality at 200 days

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Chronic GVHD Risk Score
Laboratory Tests
Criteria For Diagnosis
- Chronic Graft vs Host Disease (GVHD) Score
- Criteria for Therapeutic Response for Chronic Graft-versus-Host Disease (GVHD)
Severity, Prognosis, Stage
Complications
- Prognostic Score for Patient with Chronic Graft-versus-Host Disease After Bone Marrow Transplantation

Monitoring

Response To Therapy
Disease Progression
Complication Detection
Comorbid Conditions
- Prognostic Score for Patient with Chronic Graft-versus-Host Disease After Bone Marrow Transplantation

Specialty

Immunology/Rheumatology

Objective

laboratory tests
disease progression
complication detection

ICD-10

T86 - Failure and rejection of transplanted organs and tissues

Acute Graft vs. Host Activity Index (aGVHDAI)

Purpose: To determine the activity of acute graft vs host disease (GVHD) using the index of Leisenring et al.