Evaluation of Medication for Deterioration After Exposure to Environment

• excessive heat from sun, furnace or other heat source?

• excessive cold from winter, ice or freezer?

• immersion, rain or excessive humidity?

• excessive vibration or a crushing pressure?

• exposure to chemicals?

• a break in seals or loose caps?

• visible moisture?

• crushed or damaged container?

• change in a temperature indicator or use of a maximum temperature thermometer?

• change in a thawing indicator or use of a minimum temperature thermometer?

• leakage or debris from contents in the bottom of the case?

• degradation of paper or cardboard boxes?

• tablets sticking together?

• tablets or capsules crumbling or disintegrating?

• discoloration?

• an unusual odor?

• presence of a precipitate in a liquid solution?